Professor Randall Johnson of the Nobel Commitee, right, speaks during a news conference in Stockholm, Sweden, Monday Oct. 7, 2019. The 2019 Nobel laureates in Physiology or Medicine has been awarded to scientists Gregg L. Semenza, Peter J. Ratcliffe and William G. Kaelin Jr. receiving the award jointly for their discoveries of "how cells sense and adapt to oxygen availability". (Pontus Lundahl/TT via AP)

The Latest: Johns Hopkins celebrates Nobel laureate

October 07, 2019 - 7:09 am

STOCKHOLM (AP) — The Latest on the Nobel Prize in Medicine or Physiology (all times local):

1:05 p.m.

The Johns Hopkins University School of Medicine is celebrating one of its top researchers, Dr. Gregg Semenza, who shares this year's Nobel Prize for medicine for his work on how genes respond to low levels of oxygen.

Semenza's dean, Paul B. Rothman, says his "groundbreaking basic research has been inspired largely by what he has seen in the clinic" at Hopkins. The university says that work has "far-reaching implications in understanding the impacts of low oxygen levels in blood disorders, blinding eye diseases, cancer, diabetes, coronary artery disease, and other conditions."

The 63-year-old Semenza shares the award with William G. Kaelin Jr., professor of medicine at Harvard University and the Dana-Farber Cancer Institute who did his specialist training in internal medicine and oncology at Johns Hopkins, and Sir Peter J. Ratcliffe, professor at Oxford University and at the Francis Crick Institute.

Johns Hopkins University President Ronald J. Daniels calls it a momentous day, and says they're immensely proud of Semenza's passion for discovery, an example of the school's commitment to creating new knowledge that helps make a better and more humane world.

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1 p.m.

Reached at his home in the Boston area, Kaelin said he was half-asleep when his phone rang at 4:50 a.m.

"I was aware as a scientist that if you get a phone call at 5 a.m. with too many digits, it's sometimes very good news, and my heart started racing. It was all a bit surreal," he said.

Kaelin, who was born in the New York City borough of Queens and grew up in the city's suburbs, said the prize committee had initially been unable to find his phone number so they first reached his sister, "and that will become part of the family lore."

Kaelin said he isn't sure yet how he'll spend the prize money but "obviously I'll try to put it to some good cause."

Asked what practical payoffs have been achieved from his work, Kaelin explained that "the molecular pathway that my fellow prize winners and I helped to define converges on a protein called HIF, and as a result of this work there are now opportunities to either increase or decrease HIF."

He said drugs are being developed to do that. Certain diseases like anemia might be treated by increasing HIF, while inhibiting that protein could help with other diseases including certain cancers.

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12:50 p.m.

Dr. Andrew Murray of the University of Cambridge says the three winners of the Nobel prize in medicine "revealed the elegant mechanisms by which our cells sense oxygen levels and respond to fluctuations.

In a statement on Monday, Murray said that hypoxia — when the body doesn't have enough oxygen — is a characteristic of numerous diseases including heart failure, chronic lung disease and many cancers.

He said the work of Dr. William G. Kaelin Jr, Dr. Gregg Semenza and Dr. Peter Ratcliffe has "paved the way to greater understanding of these common, life-threatening conditions and new strategies to treat them."

12:15 p.m.

The 2019 Nobel Prize in Physiology or Medicine was given jointly to William G. Kaelin Jr, who was born in 1957 in New York City and is a professor of medicine at Harvard University; Peter Ratcliffe, 65, of the University of Oxford; and 63-year-old Gregg L. Semenza at the Johns Hopkins University School of Medicine.

The trio was given the award jointly for their discoveries of "how cells sense and adapt to oxygen availability," the Nobel Committee announced Monday.

Thomas Perlmann, the secretary of the Nobel Committee at the Sweden's Karolinska Instititute, said he was able to call the three laureates Monday, adding the last one he called was Kaelin. He reached him via his sister who gave him two phone numbers — the first one was a wrong number but he reached Kaelin on the second.

"He was really happy," Perlmann told a news conference.

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11:30 a.m.

The 2019 Nobel Prize for Physiology or Medicine has been awarded to scientists William G. Kaelin, Jr, Peter J. Ratcliffe and Gregg L. Semenza.

They received the award jointly for their discoveries of "how cells sense and adapt to oxygen availability," the Nobel Committee announced Monday.

It is the 110th prize in the category that has been awarded since 1901.

The Karolinska Institutet said in a statement the trio should share equally the 9 million kronor ($918,000) cash award.

The discoveries made by the three men "have fundamental importance for physiology and have paved the way for promising new strategies to fight anemia, cancer and many other diseases."

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8:30 a.m.

The winners of this year's Nobel Prizes are to be announced over the next week, to include two literature laureates and the coveted Nobel Peace Prize.

Events begin Monday with the award for physiology or medicine. The physics prize is handed out Tuesday and the following day is the chemistry prize.

This year's double-header Literature Prizes will be awarded Thursday and the Peace Prize will be announced on Friday.

The economics prize — officially known as the Bank of Sweden Prize in Economic Sciences in Memory of Alfred Nobel — will be awarded on Oct. 14.

The 2018 literature prize was suspended after a scandal rocked the Swedish Academy. The body plans to award it this year, along with announcing the 2019 laureate.

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Read more stories on the 2019 Nobel Prizes by The Associated Press at https://www.apnews.com/NobelPrizes

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